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| Product Name | Ciprofibrate |
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| Description | Purity >98%. Peroxisome proliferator-activated receptor Alpha (PPARAlpha) is a ligand-activated transcription factor involved in the regulation of lipid homeostasis. Activation of PPARAlpha results in expression of a variety of genes, particularly those involved in fatty acid Beta-oxidation, binding, and transport. Ciprofibrate activates PPARAlpha with an EC50 value of 20 µM and only marginally affects PPARGamma (EC50 = >300 µM). It has been shown to lower adipose tissue weight and reduce plasma insulin concentrations in obese rats and has been used clinically in the treatment of dyslipidemia. Ciprofibrate reportedly stimulates cholesteryl ester transfer protein expression and improves the flow of cholesterol through the indirect reverse cholesterol transport system, preserving plasma HDL. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methyl-propanoic acid, (±)-Ciprofibrate, WIN 35,833 |
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| Gene, Accession, CAS # | CAS: 52214-84-3 |
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| Catalog # | LS-H7153 |
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| Order / More Info | Ciprofibrate from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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