| 产品详情 |
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| Product Name | Ubiquitin Specific Peptidase 9, X-Linked (USP9X) (Isoform 2) protein (His tag) |
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| Description | Ubiquitin Specific Peptidase 9, X-linked (USP9x), also known as DFFRX, FAF and FAM, is a cytoplasmic protein that belongs to the peptidase C19 family of deubiquitinating enzymes. It is 2570 amino acids (aa) in length with a predicted molecular weight of 292. 3 kDa. Human USP9x shares 98% aa sequence identity with the mouse and rat orthologs. USP9x contains a catalytic domain located between aa 1531 and 1971 and a ubiquitin-like domain that is located at aa 873-963. It is widely expressed and has been shown to interact with and deubiquitinate multiple substrates. Some putative targets include beta-Catenin, TOR, synuclein-alpha, the ubiquitin ligases (E3s) Itch, MARCH7, and SMURF1 and the MAP kinase kinase kinase ASK1. USP9x has also been shown to control the activity of the AMPK-related kinases ARK5 and MARK4 through direct removal of Lys29- and Lys33-linked ubiquitin chains. It has also been shown to promote cell survival by deubiquitinating and stabilizing the anti-apoptotic protein Mcl-1, and to regulate chromosome alignment and segregation during mitosis by deubiquitinating the chromosome passenger protein survivin. Additionally, USP9x appears to promote TGF-beta signaling via deubiquitination of mono-ubiquitinated Smad4. USP9x expression has been shown to be correlated with several cancer types. |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | SDS-PAGE (SDS) |
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| Other Names | RGD1560056|faf|fam|dffrx|5730589N07Rik|AA407302|AA407699|AL022658|AL022749|Dffrx|FAF-X|Fafl|DFFRX|FAF|FAM |
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| Gene, Accession, CAS # | Gene ID: 8239 |
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| Catalog # | ABIN2746004 |
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| Order / More Info | Ubiquitin Specific Peptidase 9, X-Linked (USP9X) (Isoform 2) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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