| 产品详情 |
| Edit |   |
|---|
| Product Name | MIA, Recombinant, Human |
|---|
| Description | Purity ≥98% by SDS-PAGE gel and HPLC analyses. MIA is the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3)-like domain. MIA is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells that promotes melanoma metastasis by binding competitively to fibronectin and laminin in a manner that results in melanoma cell detachment from the extracellular matrix in vivo. Elevated levels of MIA may represent a clinically useful marker for diagnosis of melanoma metastasis as well as a potential marker for rheumatoid arthritis. Recombinant human MIA is a 12.2kD globular protein containing 108aa residues including two intramolecular disulfide bonds. Biological Activity: The ED50 was determined by the dose-dependant proliferation of the human A375 melanoma cell line. The expected ED50 for this effect is 4-6ug/ml. AA Sequence: MGPM |
|---|
| Size | 5ug, 20ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | MIA, Recombinant, Human (Melanoma-derived Growth Regulatory Protein, Melanoma Inhibitory Activity Protein, CD-RAP) |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 143432 |
|---|
| Price | |
|---|
| Order / More Info | MIA, Recombinant, Human from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|