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| Product Name | Recombinant Human BCL2/adenovirus E1B 19KDA protein-interacting protein 3-like (BNIP3L) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 25.9kDa. Full Length: 1-219aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Adenovirus E1B19K-binding protein B5; BCL2/adenovirus E1B 19KDA protein-interacting protein 3A; NIP3-like protein X; NIP3L |
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| Gene, Accession, CAS # | BNIP3L, UniProt: O60238 |
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| Catalog # | RPC24530 |
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| Order / More Info | Recombinant Human BCL2/adenovirus E1B 19KDA protein-interacting protein 3-like (BNIP3L) from BIOMATIK |
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| Product Specific References | n/a |
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