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| Product Name | Calpain Inhibitor I |
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| Description | Purity >95%. Calpain inhibitor I is a synthetic tripeptide aldehyde that acts as a potent inhibitor of cysteine proteases including calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). At 10-100 µM calpain inhibitor I dose-dependently prevents the degradation of I?BAlpha and I?BBeta by the ubiquitin-proteasome complex, which blocks activation of NF?B and the production of TNF and IL-1Beta, suggesting a potential therapeutic effect for inflammatory diseases. At 10 µM, calpain inhibitor I can inhibit nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-acetyl-L-leucyl-N-[(1S)-1-formylpentyl]-L-leucinamide, Ac-Leu-Leu-Nle-Aldehyde, ALLN, MG 101 |
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| Gene, Accession, CAS # | CAS: 110044-82-1 |
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| Catalog # | LS-H6971 |
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| Price | |
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| Order / More Info | Calpain Inhibitor I from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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