| 产品详情 |
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| Product Name | Recombinant Human Serine/threonine-protein phosphatase 2A activator (PPP2R4) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 60.5kDa. Full Length of Mature Protein: 2-358aa. N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged. Homo sapiens (Human). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A (i)) in presence of ATP and Mg2+. Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A (D) in presence of ATP and Mg2+ (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A (D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | PP2A, subunit B', PR53 isoform; Phosphotyrosyl phosphatase activator |
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| Gene, Accession, CAS # | PPP2R4, UniProt: Q15257 |
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| Catalog # | RPC23017 |
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| Order / More Info | Recombinant Human Serine/threonine-protein phosphatase 2A activator (PPP2R4) from BIOMATIK |
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| Product Specific References | n/a |
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