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| Product Name | PDCD6, Recombinant, Human, aa1-191, GST-Tag (Programmed Cell Death Protein 6) |
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| Description | Purity ~90% (SDS-PAGE). Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca2+-regulated signals along the death pathway. Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphoprylation of the Akt signaling pathway. Seems to play a role in the regulation of the distribution and function of MCOLN1 in the endosomal pathway. Isoform 2 has a lower Ca2+ affinity than isoform 1. Isoform 1 and, to a lesser extend, isoform 2, can stabilize SHISA5. Source: Recombinant protein corresponding to aa1-191 from human ALG2, fused to GST-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~48.9kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Apoptosis-linked gene 2 protein, Probable calcium-binding protein ALG-2 |
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| Gene, Accession, CAS # | SwissProt: O75340 |
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| Catalog # | 374643 |
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| Order / More Info | PDCD6, Recombinant, Human, aa1-191, GST-Tag (Programmed Cell Death Protein 6) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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