| 产品详情 |
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| Product Name | CRT0066101 (hydrochloride) |
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| Description | Purity >95%. Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling. The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport. CRT0066101 is an inhibitor of all three PKD isoforms (IC50 s = 1, 2.5, and 2 nM for PKD1, PKD2, and PKD3, respectively). It exhibits selectivity for PKD against a panel of >90 protein kinases, including PKCAlpha, PKBAlpha, MEK, ERK, c-Raf, c-Src, and c-Abl. It can block cell proliferation, induce apoptosis, and reduce the viability of pancreatic cancer cells both in vitro and in vivo . |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[4-[[(2R)-2-aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)-phenol, trihydrochloride |
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| Gene, Accession, CAS # | CAS: 1290629-45-6 |
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| Catalog # | LS-H7263 |
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| Price | |
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| Order / More Info | CRT0066101 (hydrochloride) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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