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| Product Name | Palmitoleoyl 3-carbacyclic Phosphatidic Acid |
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| Description | Purity >95%. Cyclic phosphatidic acids (cPAs) are naturally occurring analogs of lysophosphatidic acid (LPA) in which the sn -2 hydroxy group forms a 5-membered ring with the sn -3 phosphate. Carba-derivatives of cPA (ccPA) are modified at the sn -2 (2-ccPA) or sn -3 (3-ccPA) linkage, preventing the opening of cPA to produce lysophosphatidic acid (LPA). Palmitoleoyl 3-carbacyclic phosphatidic acid (3-ccPA 16:1) is a cyclic LPA analog that contains the 16:1 fatty acid, palmitoleate, at the sn -1 position of the glycerol backbone. At 25 µM, it inhibits the transcellular migration of MM1 cells across mesothelial cell monolayers in response to fetal bovine serum (86.9%) or LPA (99.9%) without affecting proliferation. 3-ccPA 16:1 significantly inhibits autotaxin (IC50 = 620 nM), an enzyme that is important in cancer cell survival, growth, migration, invasion and metastasis. When delivered intraperitoneally, 3-ccPA 16:1 significantly reduces the number of lung metastases formed in mice injected with B16F10 melanoma cells in the tail vein. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (2-hydroxy-2-oxido-1,2-oxaphospholan-5-yl)methyl ester-9Z-9Cl-9-hexadecenoic acid, 3-carbacyclic PA, 3-ccPA 16:1 |
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| Gene, Accession, CAS # | CAS: 910228-13-6 |
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| Catalog # | LS-H9262 |
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| Order / More Info | Palmitoleoyl 3-carbacyclic Phosphatidic Acid from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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