| 产品详情 |
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| Antigenic Specificity | SIGLEC H |
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| Clone | eBio440c |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2b, kappa |
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| Format | purified |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 2 µg/test, Immunohistochemistry: Assay-Dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | SIGLEC H Monoclonal Antibody (eBio440c), eBioscience™. Siglec-H, a protein exclusively found on pDC (plasmacytoid dendritic cells) or type I IFN-producing cells (IPC) in the naive mouse. Mouse IPC are typically PDCA+, CD11c+, CD11b-, B220+, and Ly-6C+, and are quick to respond to viruses. Siglec-H is a transmembrane protein of the Ig superfamily that like CD33 have been shown to bind sialic acid but lacks the characteristic cytoplasmic ITIM domain (immunoreceptor tyrosine based inhibitory motif). To overcome the lack of a cytoplasmic domain, Siglec-H associates with DAP12 thereby allowing for signal transduction. The eBio440c antibody has been shown to inhibit pDC function (inhbits IFNalpha secretion in response to CpG). It has been o |
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| Immunogen | n/a |
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| Other Names | Sialic Acid-Binding Immunoglobulin-Like Lectin H; SiglecH |
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| Gene, Accession # | Entrez: 233274 |
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| Catalog # | 14-0333-81 |
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| Price | |
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| Order / More Info | SIGLEC H Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 20606167, 24042114, 24890717, 25155465, 25252912, 26252890, 26341385, 27356503 |
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