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| Product Name | CNOT8, Recombinant, Human, aa1-292, GST-Tag (CCR4-NOT Transcription Complex Subunit 8) |
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| Description | Purity ~90% (SDS-PAGE). Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. Source: Recombinant protein corresponding to aa1-292 from human CNOT8, fused to GST-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~60.5kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CAF1-like protein |
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| Gene, Accession, CAS # | SwissProt: Q9UFF9 |
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| Catalog # | 372807 |
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| Order / More Info | CNOT8, Recombinant, Human, aa1-292, GST-Tag (CCR4-NOT Transcription Complex Subunit 8) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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