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| Product Name | Proteinase 3 (PR-3) |
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| Description | The Proteinase-3 (PR-3) antigen is 29kD protein found in the primary granules of neutrophils and monocytes. It is a serine protease with broad proteolytic activity against a variety of extracellular matrix proteins (1). PR-3 is purified fom a human promyelocytic cell line using detergent extraction, salt fractionation, and chromaographic techniques. Anti-neutrophil cytoplasmic antibodies (ANCA) are autoantibodies against various lysosomal enzymes (2). Staining by indirect immunofluorescence (IFA) shows two main staining patterns: cytoplasmic (c-ANCA) and perinuclear (p-ANCA) (2,3). The c-ANCA pattern is caused by autoantibodies to PR-3 (4,5). Anti-PR3 autoantibodies are found in 84-100% of patients with Wegener's granulomatosis (3,6). In addition, PR-3 antibody titer may correlate with disease activity (2). Source: Purified from a human promyelocytic cell line Applications: Suitable for use in standard solid phase immunoassays. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 208588 |
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| Price | |
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| Order / More Info | Proteinase 3 (PR-3) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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