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| Product Name | GW 0742 |
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| Description | Purity >95%. The transcription factor peroxisome proliferator-activated receptor Delta (PPARDelta) is a member of the superfamily of nuclear hormone receptors and is implicated both in lipid metabolism and in the regulation of genes with potential roles in neurotoxicity. GW 0742 is a selective PPARDelta agonist (EC50 = 1.1 nM) that exhibits 1,000-fold selectivity over the other human PPAR subtypes. GW 0742 exhibits time-dependent neuroprotection in low KCl-induced apoptosis in cerebellar granule neuronal cultures. Despite the neuroprotective properties observed, prolonged (48h) incubation with GW 0742 produced significant inherent toxicity. This cell death was determined to be apoptotic as identified with the TUNEL assay. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [4-[[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methyl phenoxy]-acetic acid |
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| Gene, Accession, CAS # | CAS: 317318-84-6 |
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| Catalog # | LS-H8046 |
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| Order / More Info | GW 0742 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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