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| Product Name | GW 501516 |
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| Description | Purity >97%. Peroxisome proliferator-activated receptor delta (PPAR delta) stimulation or over-expression in adipocytes leads to increased fatty acid oxidation, improved exercise tolerance, and resistance to obesity. GW 501516 is the first highly selective synthetic PPAR delta agonist available. GW 501516 binds to human PPAR delta with an IC50 value of 1 nM, and is at least 100-fold selective for PPAR delta compared to PPAR alpha and PPAR gamma . In obese primates, GW 501516 increases high density lipoprotein cholesterol and apolipoprotein A-1 specific reverse cholesterol transport. GW 501516 is therefore a model compound for a new type of obesity therapeutic, as well as a selective pharmacological tool for understanding lipid metabolism. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[2-methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]-acetic acid, GW1516 |
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| Gene, Accession, CAS # | CAS: 317318-70-0 |
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| Catalog # | LS-H3 |
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| Order / More Info | GW 501516 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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