| 产品详情 |
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| Product Name | GW 788388 |
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| Description | Purity >98%. GW 788388 is a selective inhibitor of transforming growth factor-Beta (TGF-Beta) type 1 receptor (TGFBR1 or ALK5; IC50 = 18 nM). It inhibits the expression of collagen type I in cells (IC50 = 93 nM) and in mice when given orally at 10 mg/kg once a day. As TGF-Beta stimulates fibrosis in a range of tissues, GW 788388 reduces typical features of fibrosis, including tissue remodeling, increased expression of Alpha-smooth muscle actin and production of collagen I. GW 788388 also blocks TGF-Beta-mediated production of VEGF by fibroblasts, as well as subsequent angiogenesis in vitro . Inhibition of ALK5 signaling by GW 788388 also induces hypertrophy in femoral growth plates in rats. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl]-N-(tetrahydro-2H-pyran-4-yl)-benzamide |
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| Gene, Accession, CAS # | CAS: 452342-67-5 |
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| Catalog # | LS-H8054 |
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| Order / More Info | GW 788388 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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