| 产品详情 |
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| Product Name | GW 7647 |
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| Description | Purity >97%. Peroxisome proliferator-activated receptor- alpha (PPAR alpha) is a ligand-activated transcription factor involved in the regulation of lipid homeostasis. Activation of PPAR alpha results in expression of a variety of genes, particularly those involved in fatty acid beta -oxidation, binding, and transport. GW 7647 is a potent, selective agonist of human and murine PPAR alpha It activates human PPAR alpha, PPAR gamma, and PPAR delta with EC50 values of 0.006, 1.1 and 6.2 µM, respectively, in a GAL4-PPAR binding assay. Similar EC50 values of 0.001, 1.3, and 2.9 were observed with the murine receptors. GW 7647 lowered triglycerides 93% and 60% in fat-fed hamsters and rats, respectively, at a dose of 3 mg/kg. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-methyl-2-[[4-[2-[[(cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-propanoic acid |
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| Gene, Accession, CAS # | CAS: 265129-71-3 |
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| Catalog # | LS-H23 |
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| Price | |
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| Order / More Info | GW 7647 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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