| 产品详情 |
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| Product Name | NBI 35965 (mesylate) |
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| Description | Purity >95%. Corticotropin-releasing hormone, also known as corticotropin-releasing factor (CRF) or corticoliberin, is a peptide hormone and neurotransmitter involved in the stress response. It is secreted from the hypothalamus and is the major regulator of pituitary corticotropin-release and consequent glucocorticoid secretion. NBI 35965 is a selective CRF receptor 1 (CRF1 ) antagonist with a Ki value of 4 nM. It does not inhibit CRF2 (Ki = >10,000 nM). NBI 35965 inhibits cAMP accumulation and adrenocorticotropic hormone (ACTH) production in vitro (pIC50 s = 7.1 and 6.9, respectively) and reduces CRF- and stress-induced ACTH production in vivo . In animal models of stress, NBI 35965 administration produces anxiolytic effects. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (7S)-6-(cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-6H-1,3,6,8a-tetraazaacenaphthylene, monomethanesulfonate |
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| Gene, Accession, CAS # | CAS: 603151-83-3 |
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| Catalog # | LS-H8928 |
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| Price | |
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| Order / More Info | NBI 35965 (mesylate) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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