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| Product Name | NMDA Receptor NR2BCT(1292-1304)-TAT (Tat-NR2BCT, H-KKNRNKLRRQHSY-Ahx-YGRKKRRQRRR-NH2) |
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| Description | Purity ~98% (HPLC). A 13-mer NMDA receptor 2B (NR2B) subunit carboxy terminal (1292-1304) derived peptide that specifically binds DAPK1 (death-associated protein kinase 1) in a reversible manner and antagonizes the activated DAPK1-NR2B interaction and the potentiation ofnMDAR function with no effect on either the catalytic activity of DAPK1 or thenMDA receptor physiology. Blocks Ca2+ influx through extrasynapticnMDA receptors (at 50uM) and the blood-brain-barrier permeable version, namely NR2BCT(1292-1304) attached to TAT(47-57) via a spacer (6-aminohexanoic acid) protects cortical neurons fromnMDA receptor-mediated insults and reduces brain infarction and improve neurological functions in mice (10mg/kg, i.v.). Sequence: H2N-Lys-Lys-Asn-Arg-Asn-Lys-Leu-Arg-Arg-Gln-His-Ser-Tyr-Ahx-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-CONH2 Formula: C143H254N64O32 Molecular Weight: 3382 Solubility: DMSO (50mg/ml) |
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| Size | 2mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217593 |
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| Order / More Info | NMDA Receptor NR2BCT(1292-1304)-TAT (Tat-NR2BCT, H-KKNRNKLRRQHSY-Ahx-YGRKKRRQRRR-NH2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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