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| Product Name | Recombinant Human Homeobox protein MOX-1 (MEOX1) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 55kDa. Full Length: 1-254aa. N-terminal GST-tagged. Homo sapiens (Human). Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Mesenchyme homeobox 1 |
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| Gene, Accession, CAS # | MEOX1, UniProt: P50221 |
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| Catalog # | RPC21660 |
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| Order / More Info | Recombinant Human Homeobox protein MOX-1 (MEOX1) from BIOMATIK |
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| Product Specific References | n/a |
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