| 产品详情 |
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| Product Name | O-7460 |
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| Description | Purity >95%. In humans, two forms of diacylglycerol lipase, DAGLAlpha and DAGLBeta, generate the endocannabinoid 2-arachidonoyl glycerol (2-AG) by attacking DAG at the sn -1 position. O-7460 is a selective inhibitor of 2-AG biosynthesis via DAGLAlpha (IC50 = 690 nM). It demonstrates much weaker inhibition towards human monoacylglycerol lipase and rat brain fatty acid amide hydrolase (IC50 s > 10 µM) and does not bind to CB1 or CB2 cannabinoid receptors (Ki s > 10 µM). At 0-12 mg/kg, i.p. in mice, O-7460 was reported to dose-dependently inhibit high-fat diet intake and reduce body weight. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[(fluoromethylphosphinyl)oxy]-1-[(1-methylethoxy)methyl]ethyl ester, 9Z-octadecenoic acid |
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| Gene, Accession, CAS # | CAS: 1572051-31-0 |
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| Catalog # | LS-H9130 |
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| Price | |
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| Order / More Info | O-7460 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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