| 产品详情 |
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| Antigenic Specificity | LFG |
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| Clone | 2C2 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2a, kappa |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | ELISA: Assay-Dependent, Immunocytochemistry: 10 µg/mL, Immunofluorescence: 10 µg/mL, Western Blot: 1-5 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | LFG Monoclonal Antibody (2C2). LFG, a seven transmembrane spanning protein, is a recently identified member of a family whose members can inhibit apoptotic cell death induced by Fas receptor. LFG is a human homolog of rat NMP35 and consists of a conserved transmembrane domain and a small cytoplasmic domain. Reports have shown that LFG protects the cell from Fas-mediated neuronal cell death in a novel way. LFG binds to Fas receptor but doesn't have any effect in reducing Fas expression or decreasing the ability of FADD binding to the receptor. Furthermore, LFG doesn't protect the cells from TNF-alpha mediated cell death process. Although LFG is ubiquitously expressed, Northern blot analysis detected an increased expression in hippocampus and |
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| Immunogen | n/a |
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| Other Names | LFG, LFG2, NGP35, NMP35, TMBIM2; fas apoptotic inhibitory molecule 2; neural membrane protein 35; protein lifeguard; transmembrane BAX inhibitor motif-containing protein 2 |
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| Gene, Accession # | Entrez: 23017; Uniprot: Q9BWQ8 |
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| Catalog # | MA5-21391 |
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| Price | |
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| Order / More Info | LFG Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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