| 产品详情 |
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| Product Name | DL-AP3 |
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| Description | Purity >95%. Metabotropic glutamate receptors (mGluR1-8) are G protein-coupled receptors that function to modulate brain excitatory signaling via presynaptic, postsynaptic, and glial mechanisms. DL-AP3 is a competitive mGluR1 antagonist that demonstrates a Ki value of 298 µM and an IC50 value of 1mM for rat mGluR1Alpha when challenged with glutamate. DL-AP3 can antagonize excitatory amino acid-induced phosphoinositide hydrolysis, induce Ca2+ mobilization in rat hippocampal slices, and inhibit phosphoserine phosphatase in rat brain cortex. At concentrations from 10-300 µM DL-AP3 has been used to characterize the role of mGluR in long-term potentiation in the hippocampus in a model of learning and memory, the release of glutamate in Parkinson's disease, and the increased activity of mGluR implicated in fragile X syndrome. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-phosphono-alanine, DL-2-Amino-3-Phosphonopropionic Acid, NSC 30078 |
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| Gene, Accession, CAS # | CAS: 5652-28-8 |
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| Catalog # | LS-H7488 |
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| Order / More Info | DL-AP3 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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