| 产品详情 |
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| Antigenic Specificity | Phospho-SMAD2 (Ser465, Ser467) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | ChIP assay: 10 µL, Immunocytochemistry: 1:250, Immunofluorescence: 1:250, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 1:500-1:2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Phospho-SMAD2 (Ser465, Ser467) Polyclonal Antibody. SMAD2 (MADH2, MAD2) regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. SMAD2 interacts with the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation into the nucleus is a central event in TGF beta signaling. Phosphorylation of threonine 8 in the calmodulin-binding region of the MH1 domain by extracellular signal regulated kinase 1 (ERK1) enhances SMAD2 transcriptional activity, which is negatively regulated by calmodulin. In response to the TGF-beta signal, SMAD2 is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the fa |
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| Immunogen | n/a |
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| Other Names | Mothers against decapentaplegic homolog 2, MAD homolog 2, Mothers against DPP homolog 2, JV18-1, Mad-related protein 2, hMAD-2, SMAD family member 2, SMAD 2, Smad2, hSMAD2, SMAD2, MADH2, MADR2, pSMAD2 |
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| Gene, Accession # | Entrez: 17126, 4087; Uniprot: Q15796, Q62432 |
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| Catalog # | 44-244G |
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| Order / More Info | Phospho-SMAD2 (Ser465, Ser467) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 23574716, 24076600, 26460952, 27011171, 27378170, 27965203, 28289141 |
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