| 产品详情 |
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| Product Name | SLF |
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| Description | Purity >98%. FK-506 is a potent immunosuppressant that forms a high affinity complex (Ki = 0.2 nM) with FK-506 binding protein 12 (FKBP12). This complex inhibits the activity of the calcium/calmodulin-dependent protein phosphatase, calcineurin, leading to disruption of T-cell activation. Synthetic ligand of FKBP (SLF) is a cell-permeable analog of FK-506 that binds tightly to FKBP but lacks the ability to inhibit calcineurin. By itself, SLF does not exhibit a significant cellular response. However, homodimers of SLF or heterodimers with another protein ligand, provide a method to promote the dimerization of ligand-specific fusion proteins to induce signaling events within a cellular environment. For example, SLF monomers connected with a 10-atom linker activates Fas signaling via Fas-FKBP fusion proteins with an EC50 of 6 nM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-(3,3-dimethyl-1,2-dioxopentyl)-(2S)-2-piperidinecarboxylic acid, (1R)-1-(3-aminophenyl)-3-(3,4-dimethoxyphenyl)propyl ester, Synthetic Ligand of FKBP |
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| Gene, Accession, CAS # | CAS: 195513-96-3 |
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| Catalog # | LS-H9946 |
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| Price | |
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| Order / More Info | SLF from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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