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| Product Name | Homoharringtonine |
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| Description | Purity >98%. Homoharringtonine is a cephalotaxine alkaloid originally isolated from C. harringtonia and a homolog of harringtonine. Homoharringtonine inhibits the chain elongation phase of translation in eukaryotes. It inhibits diphenylalanine formation by rabbit reticulocyte and human placental ribosomes in cell-free assays and binds to human 80S ribosomes with a Ka value of 2.57 x 107 M-1 (Kd = 39 nM). It also inhibits protein synthesis in vitro in P. falciparum cultured in human erythrocytes (IC50 = 4 nM). Homoharringtonine is cytotoxic and inhibits the proliferation of Jurkat acute T cell leukemia (IC50 = 9 nM) and K562 chronic myelogenous leukemia (CML) cells (IC50 = 408 µg/ml). In vivo, it decreases the number of peripheral leukemia stem cells and increases survival in CML and B cell acute lymphoblastic leukemia (B-ALL) mouse models when administered at a dose of 0.5 mg/kg. Formulations containing homoharringtonine have been used in the treatment of CML in patients with resistance and/or intolerance to two or more tyrosine kinase inhibitors. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-[4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate]cephalotaxine, CGX-635, HHT, NSC 141633, Omacetaxine Mepesuccinate |
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| Gene, Accession, CAS # | CAS: 26833-87-4 |
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| Catalog # | LS-H8122 |
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| Order / More Info | Homoharringtonine from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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