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| Product Name | Dermatopontin, Recombinant, Human (Tyrosine Rich Acidic Matrix Protein) |
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| Description | Purity ≥ 95%, as determined by SDS-PAGE under reducing conditions and visualized by silver stain.Endotoxin ≤ 1EU. Dermatopontin, also known as TRAMP (tyrosine rich acidic matrix protein), is a widely expressed noncollagenous protein component of the extracellular matrix (1, 2). Mature human Dermatopontin shares 96%, 92%, and 92% amino acid sequence identity with bovine, mouse, and rat Dermatopontin, respectively. It is a 22kD molecule that is tyrosine sulfated but not glycosylated (3, 4). Dermatopontin contains three disulfide bonded loop structures that enclose conserved hexapeptide motifs (5). It accelerates collagen fibril formation in vitro, and Dermatopontin deficient mice exhibit altered collagen matrix deposition and organization (6-8). Dermatopontin is downregulated in fibrotic growths such as leiomyoma and scar tissue (9, 10). It binds both TGF-Beta and the proteoglycan decorin, interactions that can increase the bioavailability of TGF-Beta (11, 12). Dermatopontin promotes bo |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: AAH33736 |
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| Catalog # | D3212-50 |
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| Order / More Info | Dermatopontin, Recombinant, Human (Tyrosine Rich Acidic Matrix Protein) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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