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| Product Name | Recombinant Clostridium botulinum Botulinum neurotoxin type A (botA), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 66kDa. Partial: 1-436aa. N-terminal 6xHis-SUMO-tagged. Clostridium botulinum. Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic mbrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport of the light chain from the endocytic vesicle to the cytosol. After translocation, the light chain (L) hydrolyzes the 197-Gln-|-Arg-198 bond in SNAP-25, thereby blocking neurotransmitter release. Inhibition of acetylcholine release results in flaccid paralysis, with frequent heart or respiratory failure. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Bontoxilysin-A; BOTOX |
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| Gene, Accession, CAS # | botA, UniProt: P10845 |
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| Catalog # | RPC22425 |
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| Price | |
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| Order / More Info | Recombinant Clostridium botulinum Botulinum neurotoxin type A (botA), partial from BIOMATIK |
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| Product Specific References | n/a |
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