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| Product Name | SP 141 |
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| Description | Purity >98%. Mouse double minute 2 protein (MDM2) is an E3 ubiquitin-protein ligase that binds and ubiquitinates the tumor suppressor p53, leading to its degradation by the proteasome. SP 141 is a cell-permeable inhibitor of MDM2 (Ki = 28 nM). Binding of MDM2 by SP 141 promotes its auto-ubiquitination and proteasomal degradation. SP 141 induces cell cycle arrest and apoptosis in breast and pancreatic cancer cell lines and inhibits xenograft tumor growth in vivo . This compound has a short half-life in plasma and wide tissue distribution in tumor-bearing nude mice. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole, AGN-PC-0D106I |
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| Gene, Accession, CAS # | CAS: 1253491-42-7 |
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| Catalog # | LS-H9976 |
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| Price | |
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| Order / More Info | SP 141 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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