| 产品详情 |
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| Product Name | PRT4165 |
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| Description | MW: 235.24. Purity ≥98% by HPLC. PRT4165 is a potent inhibitor of PRC1 (polycomb-repressive complex 1)-mediated histone H2A ubiquitylation in vivo and in vitro. PRT4165 inhibits the in vitro histone H2A E3 ubiquitin ligase activity of PRC1 components RING1; RNF2; and a BMI1/RNF2 complex. PRT4165 also inhibits DNA double-strand breaks induced ubiquitylation of histone H2AX. In addition; it prevents Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2alpha (Top2al |
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| Size | 5 mg, 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [2- (3-Pyridinylmethylene)-1H-Indene-1; 3 (2H)-dione; NSC600157] |
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| Gene, Accession, CAS # | CAS: 31083-55-3 |
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| Catalog # | MBS846201 |
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| Order / More Info | PRT4165 from MYBIOSOURCE INC. |
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| Product Specific References | n/a |
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