| 产品详情 |
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| Product Name | PRLX-93936 |
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| Description | An erastin analog that has antitumor activity; inhibits the HIF-1 signaling pathway under hypoxic conditions (IC50 = 0.09 µM in a cell-based reporter assay); inhibits hypoxia-induced increases in HIF-1α expression in ME-180 cervical cancer cells at 1 µM; inhibits the growth of HT-1080 fibrosarcoma, OVCAR-5 ovarian cancer, BJELR tumorigenic primary fibroblast, and PANC-1 pancreatic cancer cells (IC50s = <100 nM); inhibits tumor growth in PANC-1 and HT-1080 xenograft models at 50 mg/kg and induces tumor regression at 100 mg/kg |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PRLX93936 anti-tumor HIF1 HIF1α ME180 HT1080 OVCAR5 PANC1 |
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| Gene, Accession, CAS # | CAS: 903499-49-0 |
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| Catalog # | 25631-25 |
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| Price | |
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| Order / More Info | PRLX-93936 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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