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| Product Name | Recombinant Dictyostelium discoideum DNA-dependent protein kinase catalytic subunit (dnapkcs), partial |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 46.1kDa. Partial: 3910-4250aa. N-terminal 10xHis-tagged and C-terminal Myc-tagged. Dictyostelium discoideum (Slime mold). Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Is recruited to DNA ends by the Ku70/Ku80 heterodimer and is involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V (D)J recombination. This activity is only apparent when DNA damage is administered in G1 phase of the cell cycle. Required for efficient signaling of DNA double-stranded breaks via phosphorylation of H2AX during G1. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | n/a |
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| Gene, Accession, CAS # | dnapkcs, UniProt: Q54UC0 |
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| Catalog # | RPC25663 |
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| Order / More Info | Recombinant Dictyostelium discoideum DNA-dependent protein kinase catalytic subunit (dnapkcs), partial from BIOMATIK |
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| Product Specific References | n/a |
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