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| Product Name | Recombinant Human Suppressor of cytokine signaling 1 (SOCS1) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 27.6kDa. Full Length: 1-211aa. N-terminal 6xHis-tagged. Homo sapiens (Human). SOCS family proteins form part of a classical negative feedback syst that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ses to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | JAK-binding protein; JABSTAT-induced STAT inhibitor 1; SSI-1Tec-interacting protein 3; TIP-3 |
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| Gene, Accession, CAS # | SOCS1, UniProt: O15524 |
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| Catalog # | RPC20088 |
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| Order / More Info | Recombinant Human Suppressor of cytokine signaling 1 (SOCS1) from BIOMATIK |
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| Product Specific References | n/a |
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