| 产品详情 |
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| Product Name | Sirtinol |
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| Description | Purity >98%. Sirtinol is a cell-permeable inhibitor of sirtuin NAD+ -dependent deacetylases, inhibiting the yeast sirtuin Sir2p with an IC50 value of 68 µM and the human sirtuins SIRT1 and SIRT2 with IC50 values of 131 and 38 µM, respectively. It does not alter HDAC1 activity. Sirtinol inhibits the growth of cancer cells and suppresses inflammatory signaling in human dermal microvascular endothelial cells. In plants, sirtinol can be metabolized to 2-hydroxy-1-naphthoic acid, which activates auxin signaling and alters plant growth and development. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[[(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)-benzamide, Sir Two Inhibitor Naphthol |
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| Gene, Accession, CAS # | CAS: 410536-97-9 |
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| Catalog # | LS-H9931 |
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| Order / More Info | Sirtinol from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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