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| Product Name | MDL 29951 |
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| Description | Purity >97%. NMDA receptors are neuroreceptors that have binding sites for glycine or D-serine as well as L-glutamate. MDL 29951 is an antagonist of NMDA receptors with high affinity for the glycine binding site (Ki = 140 nM). It is functional both in vitro and in vivo. MDL 29951 blocks NMDA receptor-dependent convulsions in audiogenic seizure-susceptible DBA/2J mice. It is used to evaluate the role of the glycine site of the NMDA receptor in neurological signaling. MDL 29951 is also an agonist of the G protein-coupled receptor GPR17 (EC50 values range from 7 nM to 6 µM, depending on the assay). GPR17 is thought to be involved in oligodendrocyte differentiation and myelin formation/repair. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-carboxy-4,6-dichloro-1H-indole-3-propanoic acid |
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| Gene, Accession, CAS # | CAS: 130798-51-5 |
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| Catalog # | LS-H124 |
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| Order / More Info | MDL 29951 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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