| 产品详情 |
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| Antigenic Specificity | IKK beta |
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| Clone | J.414.5 |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, nonhuman primate, rat |
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| Isotype | IgG |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | IKK beta Monoclonal Antibody (J.414.5). Inhibitor of nuclear factor kappa-B kinase subunit beta (IKK beta) is a serine kinase that plays an essential role in the NF-kaapa-B signaling pathway which is activated by mulitple stimuli such as inflammatory cytokines, bacterial, or viral products, DNA damages, or other cellular stresses. IKK beta acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune |
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| Immunogen | n/a |
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| Other Names | I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; inhibitor of nuclear factor kappa-B kinase subunit beta; nuclear factor NF-kappa-B inhibitor kinase beta |
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| Gene, Accession # | Entrez: 16150, 3551, 84351; Uniprot: O14920, O88351, Q9QY78 |
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| Catalog # | MA5-15080 |
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| Price | |
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| Order / More Info | IKK beta Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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| 产品资料 |
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