| 产品详情 |
| Edit |   |
|---|
| Product Name | CL 387,785 |
|---|
| Description | Purity >95%. Overactivity of epidermal growth factor receptor (EGFR) tyrosine kinase activity has been associated with a number of cancers. CL 387,785 is a potent, irreversible inhibitor of EGFR kinase activity (IC50 = 370 pM). It blocks EGF-stimulated autophosphorylation of receptors in cells (IC50 = 5 nM) and halts cell cycling in cells that overexpress EGFR or c-ErbB2 (IC50 s = 31-125 nM). CL 387,785 profoundly blocks the growth of EGFR-overexpressing tumors in nude mice when given orally at 80 mg/kg/day for 10 days. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide, EKI-785, EKB-785, WAY-EKI-785 |
|---|
| Gene, Accession, CAS # | CAS: 194423-06-8 |
|---|
| Catalog # | LS-H7183 |
|---|
| Price | |
|---|
| Order / More Info | CL 387,785 from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|