| 产品详情 |
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| Product Name | PKR Inhibitor |
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| Description | Purity >95%. The activity of double-stranded RNA-activated protein kinase (PKR) is altered by viral infection as well as by various neuropathologies. A primary phosphorylation target of PKR is eukaryotic initiation factor 2 subunit Alpha (eIF2Alpha), blocking translation and driving apoptosis. PKR Inhibitor is an oxindole/imidazole derivative that binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM. PKR Inhibitor protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress. It also prevents phosphorylation of Fas-associated protein with a death domain (FADD) in neuroblastoma cells, preventing FADD-dependent activation of caspases and apoptosis. Intraperitoneal administration of PKR inhibitor in rats reduces phosphorylation of PKR and eIF2Alpha in the brain. Similar administration in mice enhances long-term memory storage, including contextual and auditory long-term fear memories. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6,8-dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one, C16, GW 506033X, Protein Kinase RNA-activated |
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| Gene, Accession, CAS # | CAS: 608512-97-6 |
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| Catalog # | LS-H9450 |
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| Order / More Info | PKR Inhibitor from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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