| 产品详情 |
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| Product Name | Erbstatin analog |
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| Description | Purity >97%. Overactivity of the epidermal growth factor (EGF) receptor-associated tyrosine kinase has been associated with a number of cancers and thus tyrosine kinase inhibitors could be potential therapeutic agents to prevent malignant growth. Erbstatin is a potent, small-molecule inhibitor of EGF receptor-associated tyrosine kinase. However, it is highly unstable, inactivating completely within 30 minutes in calf serum. Erbstatin analog is a stable, potent inhibitor of EGFR kinase activity. It is four-times more stable than erbstatin in calf serum and inhibits EGFR tyrosine kinase in vitro similar to erbstatin with an IC50 value of 0.14 ug/ml. Erbstatin analog inhibits EGF-stimulated growth in EGFR-overexpressing NIH3T3 cells with an IC50 value of 0.5 ug/ml and efficiently delays the onset of EGF-induced DNA synthesis. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-(2,5-dihydroxyphenyl)-2-propenoic acid, methyl ester, Methyl 2,5-dihydoxycinnamate |
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| Gene, Accession, CAS # | CAS: 63177-57-1 |
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| Catalog # | LS-H37 |
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| Price | |
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| Order / More Info | Erbstatin analog from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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