| 产品详情 |
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| Product Name | Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3) protein |
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| Description | Ubiquitin-conjugating Enzyme H5c (UbcH5c), also known as ubiquitin-conjugating Enzyme E2D 3 (UBE2D3), is a member of the yeast Ubc4/5 family of ubiquitin-conjugating (E2) enzymes. Human UbcH5c/UBE2D3 has a predicted molecular weight of 17 kDa and shares 88% and 89% amino acid sequence identity with the related family members, UbcH5a and UbcH5b, respectively. In combination with ubiquitin ligases (E3s) such as CHIP, UbcH5c/UBE2D3 mediates the ubiquitination and subsequent degradation of several regulatory proteins. For instance, UbcH5c/UBE2D3 is involved in the poly-ubiquitination and proteasome-mediated degradation of the NF-kappaB inhibitor, IkappaB-alpha, and is implicated in NF-kappaB-dependent inflammation. UbcH5c/UBE2D3 also mediates the ubiquitination of Histone H2A and PCNA, suggesting that it functions during transcriptional regulation, DNA replication and DNA damage responses. |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | SDS-PAGE (SDS) |
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| Other Names | UBE2D3P|Xubc4|e2(17)kb3|ubc4/5|ubch5c|ube2d3.1|E2(17)KB3|UBC4/5|UBCH5C|eff|fb36f02|wu:fb36f02|zgc:56340|ube2d2|xubc4|1100001F19Rik|9430029A22Rik|AA414951 |
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| Gene, Accession, CAS # | Gene ID: 7323 |
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| Catalog # | ABIN2745905 |
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| Order / More Info | Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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