| 产品详情 |
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| Product Name | Ubiquitin-Conjugating Enzyme E2D 1 (UBE2D1) protein (GST tag) |
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| Description | Ubiquitin-conjugating Enzyme H5a (UbcH5a), also known as ubiquitin-conjugating Enzyme E2D 1 (UBE2D1), is a ubiquitously expressed protein that is related to Stimulator of Iron Transport (SFT). Human UbcH5a/UBE2D1 has a predicted molecular weight of 17 kDa and shares 89% and 88% amino acid (aa) sequence identity with the related family members UbcH5b and UbcH5c, respectively. Human UbcH5a/UBE2D1 shares 100% aa sequence identity with the mouse and rat orthologs. UbcH5a/UBE2D1 has a conserved E2 catalytic core domain that contains an active site cysteine residue, and it interacts with a variety of HECT and RING finger ubiquitin ligases (E3) to mediate the ubiquitination of specific target proteins. UbcH5a/UBE2D1 interacts with the E3, E6-AP, to conjugate ubiquitin to the tumor suppressor, p53. Additional protein targets of UbcH5a/UBE2D1 include c-Fos, RIP1, and HIF-1. Pathologically, UbcH5a/UBE2D1 is implicated in protein degradation during cancer and immune responses. |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | SDS-PAGE (SDS) |
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| Other Names | e2(17)kb1|sft|ubc4/5|ubch5|ubch5a|E2(17)KB1|SFT|UBC4/5|UBCH5|UBCH5A|ube2d1|wu:fc16h06|zgc:73096 |
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| Gene, Accession, CAS # | Gene ID: 7321 |
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| Catalog # | ABIN2745900 |
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| Order / More Info | Ubiquitin-Conjugating Enzyme E2D 1 (UBE2D1) protein (GST tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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