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| Product Name | Rhein |
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| Description | Purity >95%. Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein . At 10 µM, rhein inhibits IL-1Beta signaling, suppressing signaling through NF-?B, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13. It inhibits IKKBeta (IC50 = 11.8 µM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically increasing TNF-Alpha, IL-1Beta, and HMBG1 expression. Rhein shows efficacy against pancreatic fibrosis, chronic pancreatitis, and hyperglycemia-induced pancreatic Beta-cell apoptosis. It also inhibits angiogenesis of breast cancer cells under normoxic and hypoxic conditions. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid, NSC 38629, Rheic Acid |
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| Gene, Accession, CAS # | CAS: 478-43-3 |
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| Catalog # | LS-H9703 |
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| Order / More Info | Rhein from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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