| 产品详情 |
| Edit |   |
|---|
| Product Name | TAE684 |
|---|
| Description | Purity >95%. Human anaplastic lymphoma kinase (ALK) is an oncogene that is amplified in neuroblastomas and when juxtaposed with various fusion partners, its constitutive kinase activity is associated with the development of a type of anaplastic large cell lymphoma (ALCL). TAE684 is an ALK inhibitor that blocks the proliferation of ALCL-derived and ALK-dependent cell lines with IC50 values of 2-5 nM. When tested against a panel of 35 cells transformed by various tyrosine kinases, TAE684 demonstrated 100- to 1,000-fold selectivity for inhibiting ALK-driven cell proliferation. TAE684 treatment induces cell cycle arrest and apoptosis in ALK-dependent cell lines and has been used to suppress tumor growth in in vivo models of ALK-positive ALCL and neuroblastoma. TAE684 is also reported to inhibit the activity of the Parkinson's disease-linked leucine-rich repeat kinase 2 (IC50 s = 7.8 and 6.1 nM for wild-type and G2019S mutant LRRK2, respectively). |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 5-chloro-N2 -[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4 -[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-pyrimidinediamine, NVP-TAE684 |
|---|
| Gene, Accession, CAS # | CAS: 761439-42-3 |
|---|
| Catalog # | LS-H10089 |
|---|
| Price | |
|---|
| Order / More Info | TAE684 from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|