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| Product Name | Beta-Amyloid 1-42 Ligand Screening Assay Kit (Fluorometric) |
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| Description | Alzheimer's disease is a chronic neurodegenerative disease. It is caused by accumulation of amyloid plaques that can be found in the brains of patients suffering this condition. Plaques are mainly composed of Beta amyloid (ABeta) peptides: ABeta (1-40) and ABeta (1-42). Recent studies showed that two Beta Amyloid peptides (ABeta (1-40) and ABeta (1-42)) exist in brain tissues, cerebrospinal fluid (CSF) and plasma in patients suffering from Alzheimer's disease. In particular, aggregated ABeta (1-42) is considered a validated biomarker for diagnosing Alzheimer's disease. Therefore, screening ABeta42 Ligands that could prevent aggregation is critical for developing potential therapeutic treatments. In The Beta Amyloid 1-42 (ABeta42) Ligand Screening kit, a dye binds to the beta sheets of an aggregated amyloid peptide resulting in an intense fluorescent product (Ex/Em: 440/490 nm). In the presence of an ABeta42 ligand, this reaction is impeded/abolished resulting in decrease or total loss of fluorescence. This assay is useful in screening of ABeta42 ligands for developing potential therapeutic agents against Alzheimer's disease. The assay is simple, reliable and high-throughput adaptable screening assay |
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| Size | n/a |
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| Applications | Rapid, high-throughput screening of drugs and novel ligands. . Development of structure-activity relationship (SAR) models to predictABeta42/ligand interaction liability of novel compounds. |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | LS-K577 |
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| Order / More Info | Beta-Amyloid 1-42 Ligand Screening Assay Kit (Fluorometric) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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