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| Antigenic Specificity | Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) (aa 1201-1215), (C-Term) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat |
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| Isotype | n/a |
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| Format | immunogen affinity purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Low-density lipoprotein receptor-related protein 5 is a protein that in humans is encoded by the LRP5 gene. It is mapped to 11q13.2. LRP5 is a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with diabetes mellitus type 1 in humans. This protein plays a key role in skeletal homeostasis. In addition to that, the binding of axin to LRP5 is an important part of the Wnt signal transduction pathway, and it also acts as a target for the inhibitory effects of Dickkopf, another developmental protein, on Wnt signaling. |
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| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human LRP5(1201-1215aa IHAVEEVSLEEFSAH), identical to the related mouse and rat sequences. |
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| Other Names | Xlrp5|bmnd1|evr1|evr4|hbm|lr3|lrp5-A|lrp7|oppg|ops|opta1|vbch2|LRP5|LRP6|BMND1|EVR1|EVR4|HBM|LR3|LRP7|OPPG|OPS|OPTA1|VBCH2|mKIAA4142 |
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| Gene, Accession # | Gene ID: 16973,293649 |
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| Catalog # | ABIN1889221 |
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| Order / More Info | Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) (aa 1201-1215), (C-Term) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 11336703 |
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