| 产品详情 |
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| Product Name | CCT251545 |
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| Description | Purity >95%. CCT251545 is an orally bioavailable inhibitor of Wnt signaling (IC50 = 5 nM). It is a potent and selective inhibitor of the human mediator complex-associated protein kinases Cdk8 and Cdk19. Through its effects on Cdk8 and Cdk19, CCT251545 alters Wnt pathway-regulated gene expression. It reduces tumor growth in COLO 205 human colon cancer xenografts after oral dosing (70 mg/kg bid) and in Wnt-dependent tumors. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 8-[3-chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-pyridinyl]-2,8-diazaspiro[4.5]decan-1-one |
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| Gene, Accession, CAS # | CAS: 1661839-45-7 |
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| Catalog # | LS-H7034 |
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| Price | |
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| Order / More Info | CCT251545 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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