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| Product Name | 2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) (AA 1-364) protein (His tag) |
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| Description | OAS1 enzyme is a member of the 2',5'-oligoadenylate synthetase family. OAS1 is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates(2-5As). These molecules in turn activate latent RNase L resulting in viral RNA degradation and the inhibition of viral replication. OAS1 may have a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS1 binds double-stranded RNA and polymerizes ATP into PPP (A2'P5'A)N oligomers, which activate the latent RNase L that, once activated, cleaves single-stranded RNAs. OAS1 gene mutations are been linked to host susceptibility to viral infection. OSA1 gene polymorphisms are linked to the outcome of hepatitis C virus infection. Furthermore, OAS1 gene polymorphisms are linked to the susceptibility to severe acute respiratory syndrome Synonyms: 2'-5'-oligoadenylate synthetase 1, (2-5')oligo(A) synthetase 1, 2-5A synthetase 1, p46/p42 OAS, E18/E16, OAS1, OIAS, IFI-4, OIASI |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | OAS1|Oas1|Oas1g|Flv|L1|Mmu-L1|Oias-2|Oias2|Wnv|IFI-4|OIAS|OIASI |
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| Gene, Accession, CAS # | Gene ID: 4938 |
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| Catalog # | ABIN805783 |
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| Order / More Info | 2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) (AA 1-364) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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