| 产品详情 |
| Edit |   |
|---|
| Product Name | GSK-J5 (hydrochloride) |
|---|
| Description | Purity >95%. The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer. GSK-J4 is a cell-permeable prodrug which is modified by intracellular esterases to give GSK-J1 , an inhibitor of JMJD3. GSK-J5 is a pyridine regio-isomer of GSK-J4. Like GSK-J4, this isomer is cell-permeable and hydrolyzed to a free base. However, the free base is a weak inhibitor of JMJD3 (IC50 > 100 µM), making it an ideal inactive control molecule for elucidating the functional role of JMJD3 inhibition. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | N-[2-(3-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-Beta-alanine, ethyl ester, monohydrochoride |
|---|
| Gene, Accession, CAS # | CAS: 1797983-32-4 |
|---|
| Catalog # | LS-H8035 |
|---|
| Price | |
|---|
| Order / More Info | GSK-J5 (hydrochloride) from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|