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| Product Name | GSK-LSD1 (hydrochloride) |
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| Description | Purity >98%. Lysine-specific demethylase 1 (LSD1) belongs to the family of flavin adenine dinucleotide (FAD)-dependent amine oxidases that include monoamine oxidases (MAOs) and polyamine oxidase (PAO). LSD1 specifically demethylates mono- and dimethylated histone H3 lysine 4, resulting in transcriptional repression. It also controls the tumor suppressor activity of p53 by demethylating a specific p53 lysine residue (LYS370 ). GSK-LSD1 is an irreversible, mechanism-based inhibitor of LSD1 (IC50 = 16 nM) that is >1,000-fold selective over the closely related FAD-utilizing enzymes LSD2, MAO-A, and MAO-B. GSK-LSD1 induces gene expression changes in various cancer cell lines, inhibiting their proliferation (EC50 s <5 nM). See the Structural Genomics Consortium (SGC) website for more information. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[(1R,2S)-2-phenylcyclopropyl]-4-piperidinamine, dihydrochloride |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | LS-H8034 |
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| Order / More Info | GSK-LSD1 (hydrochloride) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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