| 产品详情 |
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| Antigenic Specificity | BR serine/threonine Kinase 2 (BRSK2) (aa 660-710) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | serum |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (IHC),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | FUNCTION: Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion, BRSK2 phosphorylated at Thr-260 can promote insulin secretion. Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmatic reticulum (ER) stress. Subcellular location: Cytoplasm > cytoskeleton > centrosome. Cytoplasm > perinuclear region. Endoplasmic reticulum. Note: Detected at centrosomes during mitosis. Localizes to the endoplasmic reticulum in response to stress caused by tunicamycin. Tissue specificity: Detected in pancreas islets.Synonyms: Serine/threonine protein kinase BRSK2, Brain selective kinase 2, Brain specific serine/threonine protein kinase 2, BR serine/threonine protein kinase 2, Serine/threonine-protein kinase 29, Serine/threonine-protein kinase SAD-A, C11orf7, PEN11B, SADA, STK29 |
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| Immunogen | A synthetic peptide to from aa region 660-710 of human BRSK2 conjugated to an immunogenic carrier protein was used as the antigen. |
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| Other Names | BRSK2|C11orf7|PEN11B|SAD1|SADA|STK29|4833424K13Rik|SAD-A |
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| Gene, Accession # | Gene ID: 9024,75770,293631 |
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| Catalog # | ABIN1841835 |
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| Price | |
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| Order / More Info | BR serine/threonine Kinase 2 (BRSK2) (aa 660-710) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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