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| Product Name | Mouse OSM / Oncostatin M Protein (Recombinant) |
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| Description | Purity >95% by SDS-PAGE and HPLC, MW: 20.5 kDa (SDS-PAGE). Oncostatin M (OSM) is a multifunctional cytokine, and belongs to Interleukin-6 (IL-6) subfamily, which also includes IL-11, leukemia inhibitory factor (LIF), ciliary neurotropic factor, cardiotrophin-1, and novel neurotropin-1. In vivo, OSM is secreted from activated T cells, monocytes, neutrophils, and endothelial cells. OSM is related to LIF, and shares a receptor with LIF in human. Human OSM can bind to gp130 and recruit OSM Receptor Beta or LIF Receptor Beta to form a ternary complex. OSM stimulates the growth of different types of cells, including megakaryocytes, fibroblasts, vascular endothelial cells, and T cells. OSM inhibits the proliferation of several cancer cell lines, such as solid tissue tumor cells, lung cancer cells, melanoma cells, and breast cancer cells. Recombinant Mouse Oncostatin M (rmOSM) produced in E. coli is a single non-glycosylated polypeptide chain containing 182 amino acids. A fully biologically active molecule, rmOSM has a molecular mass of 20.5 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | OSM, Oncostatin-M, Oncostatin M |
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| Gene, Accession, CAS # | OSM, Gene ID: 5008 |
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| Catalog # | LS-G27106 |
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| Order / More Info | Mouse OSM / Oncostatin M Protein (Recombinant) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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